197 research outputs found
Affine Registration of label maps in Label Space
Two key aspects of coupled multi-object shape\ud
analysis and atlas generation are the choice of representation\ud
and subsequent registration methods used to align the sample\ud
set. For example, a typical brain image can be labeled into\ud
three structures: grey matter, white matter and cerebrospinal\ud
fluid. Many manipulations such as interpolation, transformation,\ud
smoothing, or registration need to be performed on these images\ud
before they can be used in further analysis. Current techniques\ud
for such analysis tend to trade off performance between the two\ud
tasks, performing well for one task but developing problems when\ud
used for the other.\ud
This article proposes to use a representation that is both\ud
flexible and well suited for both tasks. We propose to map object\ud
labels to vertices of a regular simplex, e.g. the unit interval for\ud
two labels, a triangle for three labels, a tetrahedron for four\ud
labels, etc. This representation, which is routinely used in fuzzy\ud
classification, is ideally suited for representing and registering\ud
multiple shapes. On closer examination, this representation\ud
reveals several desirable properties: algebraic operations may\ud
be done directly, label uncertainty is expressed as a weighted\ud
mixture of labels (probabilistic interpretation), interpolation is\ud
unbiased toward any label or the background, and registration\ud
may be performed directly.\ud
We demonstrate these properties by using label space in a gradient\ud
descent based registration scheme to obtain a probabilistic\ud
atlas. While straightforward, this iterative method is very slow,\ud
could get stuck in local minima, and depends heavily on the initial\ud
conditions. To address these issues, two fast methods are proposed\ud
which serve as coarse registration schemes following which the\ud
iterative descent method can be used to refine the results. Further,\ud
we derive an analytical formulation for direct computation of the\ud
"group mean" from the parameters of pairwise registration of all\ud
the images in the sample set. We show results on richly labeled\ud
2D and 3D data sets
Diffusion Driven Label Fusion for White Matter Multi-Atlas Segmentation
International audienceWhite matter pathologies such as tumors or traumatic brain injury disrupt the structure of white matter. These disruptions hamper the inference of affected pathways using tractography. A way to overcome this is to use a label fusion technique. Label fusion aims to infer the localization of the brain structure of a subject from its localization in a group of control subjects. The most common technique is known as the voting rule, where a structure is said to be present in a voxel if it's present in the majority of the voting subjects. Furthermore, this can be improved by weighting each vote by the similarity between the T1 of each voting subject and the subject to be inferred. However, these techniques only relay in the spatial localization of the structures. In this work, we introduce a way to weight the vote of each subject based on how the voted pathway is supported by the test subject's diffusion data. This is, if the diffusion data of the test subject is consistent with the direction of the voted pathway, the vote has a higher weight. We show that adding dMRI to the label fusion process achieves a similar number of true positives than the voting technique, with a 60% less of false positives. However, this incurs in a trade-off of a 40% false negatives
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Medial Frontal White and Gray Matter Contributions to General Intelligence
The medial orbitofrontal cortex (mOFC) and rostral anterior cingulate cortex (rACC) are part of a wider neural network that plays an important role in general intelligence and executive function. We used structural brain imaging to quantify magnetic resonance gray matter volume and diffusion tensor white matter integrity of the mOFC-rACC network in 26 healthy participants who also completed neuropsychological tests of intellectual abilities and executive function. Stochastic tractography, the most effective Diffusion Tensor Imaging method for examining white matter connections between adjacent gray matter regions, was employed to assess the integrity of mOFC-rACC pathways. Fractional anisotropy (FA), which reflects the integrity of white matter connections, was calculated. Results indicated that higher intelligence correlated with greater gray matter volumes for both mOFC and rACC, as well as with increased FA for left posterior mOFC-rACC connectivity. Hierarchical regression analyses revealed that DTI-derived FA of left posterior mOFC-rACC uniquely accounted for 29%–34% of the variance in IQ, in comparison to 11%–16% uniquely explained by gray matter volume of the left rACC. Together, left rACC gray matter volume and white matter connectivity between left posterior mOFC and rACC accounted for up to 50% of the variance in general intelligence. This study is to our knowledge the first to examine white matter connectivity between OFC and ACC, two gray matter regions of interests that are very close in physical proximity, and underscores the important independent contributions of variations in rACC gray matter volume and mOFC-rACC white matter connectivity to individual differences in general intelligence
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Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury
A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology of these symptoms and there is often no radiological evidence based on conventional clinical imaging. We aimed to utilize methods to evaluate microstructural tissue changes and to determine whether or not a link with PPCS was present. A novel analysis method was developed to identify abnormalities in high-resolution diffusion tensor imaging (DTI) when the location of brain injury is heterogeneous across subjects. A normative atlas with 145 brain regions of interest (ROI) was built from 47 normal controls. Comparing each subject’s diffusion measures to the atlas generated subject-specific profiles of injury. Abnormal ROIs were defined by absolute z-score values above a given threshold. The method was applied to 11 PPCS patients following mTBI and 11 matched controls. Z-score information for each individual was summarized with two location-independent measures: “load” (number of abnormal regions) and “severity” (largest absolute z-score). Group differences were then computed using Wilcoxon rank sum tests. Results showed statistically significantly higher load (p = 0.018) and severity (p = 0.006) for fractional anisotropy (FA) in patients compared with controls. Subject-specific profiles of injury evinced abnormally high FA regions in gray matter (30 occurrences over 11 patients), and abnormally low FA in white matter (3 occurrences over 11 subjects). Subject-specific profiles provide important information regarding the pathology associated with PPCS. Increased gray matter (GM) anisotropy is a novel in-vivo finding, which is consistent with an animal model of brain trauma that associates increased FA in GM with pathologies such as gliosis. In addition, the individualized analysis shows promise for enhancing the clinical care of PPCS patients as it could play a role in the diagnosis of brain injury not revealed using conventional imaging
Shape analysis based on depth-ordering
In this paper we propose a new method for shape analysis based on the ordering of shapes using band-depth. We use this band-depth to non-parametrically define a global depth for a shape with respect to a reference population, typically consisting of normal control subjects. This allows us to globally quantify differences with respect to “normality”. Using the depth-ordering of shapes also allows the detection of localized shape differences by using α-central values of shapes. We propose permutation tests to statistically assess global and local shape differences. We further determine the directionality of shape differences (local inflation versus deflation). The method is evaluated on a synthetically generated striatum dataset, and applied to detect shape differences in the hippocampus between subjects with first-episode schizophrenia and normal controls
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Directional functions for orientation distribution estimation
Computing the Orientation Distribution Function (ODF) from High Angular Resolution Diffusion Imaging (HARDI) signals makes it possible to determine the orientation of fiber bundles of the brain. The HARDI signals are samples measured from a spherical shell and thus require processing on the sphere. Past work on ODF estimation involved using the spherical harmonics or spherical radial basis functions. In this work, we propose three novel directional functions able to represent the measured signals in a very compact manner, i.e., they require very few parameters to completely describe the measured signal. Analytical expressions are derived for computing the corresponding ODF. The directional functions can represent diffusion in a particular direction and mixture models can be used to represent multi-fiber orientations. We show how to estimate the parameters of this mixture model and elaborate on the differences between these functions. We also compare this general framework with estimation of ODF using spherical harmonics on some real and synthetic data. The proposed method could be particularly useful in applications such as tractography and segmentation. Details are also given on different ways in which interpolation can be performed using directional functions. In particular, we discuss a complete Euclidean as well as a “hybrid” framework, comprising of the Riemannian as well as Euclidean spaces, to perform interpolation and compute geodesic distances between 2 ODF’s
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Fiber Bundle Estimation and Parameterization
Individual white matter fibers cannot be resolved by current magnetic resonance (MR) technology. Many fibers of a fiber bundle will pass through an individual volume element (voxel). Individual visualized fiber tracts are thus the result of interpolation on a relatively coarse voxel grid, and an infinite number of them may be generated in a given volume by interpolation. This paper aims at creating a level set representation of a fiber bundle to describe this apparent continuum of fibers. It further introduces a coordinate system warped to the fiber bundle geometry, allowing for the definition of geometrically meaningful fiber bundle measures
A prospective study of physician-observed concussion during a varsity university hockey season: White matter integrity in ice hockey players. Part 3 of 4
Object: The aim of this study was to investigate the effect of repetitive head impacts on white matter integrity that were sustained during 1 Canadian Interuniversity Sports (CIS) ice hockey season, using advanced diffusion tensor imaging (DTI). Methods: Twenty-five male ice hockey players between 20 and 26 years of age (mean age 22.24 ± 1.59 years) participated in this study. Participants underwent pre- and postseason 3-T MRI, including DTI. Group analyses were performed using paired-group tract-based spatial statistics to test for differences between preseason and postseason changes. Results: Tract-based spatial statistics revealed an increase in trace, radial diffusivity (RD), and axial diffusivity (AD) over the course of 1 season. Compared with preseason data, postseason images showed higher trace, AD, and RD values in the right precentral region, the right corona radiata, and the anterior and posterior limb of the internal capsule. These regions involve parts of the corticospinal tract, the corpus callosum, and the superior longitudinal fasciculus. No significant differences were observed between preseason and postseason for fractional anisotropy. Conclusions: Diffusion tensor imaging revealed changes in white matter diffusivity in male ice hockey players over the course of 1 season. The origin of these findings needs to be elucidated
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